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Tadalafil vs sildenafil: Which One to Choose for ED?

Tadalafil vs sildenafil: Which One to Choose for ED?

Tadalafil vs. Sildenafil: Optimize your performance with insights on these popular ED medications. Make the right choice today!

Tadalafil vs sildenafil

Tadalafil vs. sildenafil: Many factors contribute to these problems in men such as stress, age, lifestyle, etc. Sildenafil is the generic name of the ED medicine Viagra and Tadalafil is the generic name of Cialis. Today, men do not have to worry about dealing with ED and PE problems as several medicines are available to help them attain a hard and long-lasting erection. Medicines like Tadalafil and Sildenafil are popular ED medicines that help men attain stiff erections upon sexual stimulation. Both are PDE5 inhibitors that relax the muscles in the penile region. It helps males enjoy sex through firm erections.

Apart from the two medicines, other ED medicines that you can try to get results for ED are Taxyn and Stendra. If you are wondering which of the two medicines is good for you, then you need to compare them based on their efficacy, how they work, price, etc.

So let us begin and compare them to find out which is best for you. While comparing Tadalafil vs Sildenafil we will start with different aspects.

Tadalafil vs. sildenafil: Which of the two works quicker?

Here, Tadalafil works faster than Sildenafil with a difference of 10-20 minutes. Sildenafil starts working within 30-60 minutes after taking it. Tadalafil starts working within 20-30 minutes after taking it.

Again, it depends on the person and his response to each medication. Both medicines work best when taken without food. Taking them after having food can delay the time it takes to work.


Tadalafil – Available in different doses in 2.5mg, 5mg, 10mg, 20mg and tadalafil 40 mg
Sildenafil – Available in 25mg, 50mg, and 100mg

Which ED medicine lasts longer Tadalafil vs. sildenafil?

Tadalafil (Cialis) lasts longer as compared to Sildenafil. Sildenafil lasts up to 4 hours. Tadalafil lasts for nearly 36 hours. Well, it doesn’t mean that you will have a continuous erection for the duration each medicine is active. It means you can attain an erection when a male is sexually stimulated for that period when the medicine is active.

Tadalafil earns the tag of “The Weekend Pill”. It means men do not need to plan the dosage before expecting sexual activity. Instead, it helps you utilize the results up to 12 to 36 hours after consuming it. Tadalafil 2.5mg & 5mg is the daily dose. You can take it every day. It is suitable for men having more than two sexual encounters/per week.


Tadalafil versus Sildenafil- Which of the two has fewer side effects?

Both these medicines have the same side effects, but the side effects related to Tadalafil remain for longer because of its longer duration of action. Both medicines have a side effect in common – Headache. You may face facial flushing and nasal congestion as a side effect of both medicines.

Tadalafil vs. Sildenafil – Price Comparison

Tadalafil is less costly than sildenafil.

Generic Sildenafil offers a cost-effective treatment.

Conditions Treated – Tadalafil vs. Sildenafil 

Tadalafil helps treat ED and is approved to treat symptoms and signs of an enlarged prostate (BPH). It also treats PAH or high blood pressure in your lungs. Sildenafil is FDA FDA-approved medicine to treat erectile dysfunction and treats PAH. The doctor prescribes these medicines to treat sexual issues in males related to orgasm, the release of sperm, and complete sexual satisfaction.

Tadalafil shows the best results in enhancing sperm-releasing efficiency and the ability to reach an orgasm in the male. Sildenafil helps males with issues like the early release of sperm by improving their sperm release control.

Drug interactions: Tadalafil versus Sildenafil

The two medicines are PDE5 inhibitors and come with the same drug interactions. Using these two medicines together can drop blood pressure, so do not attempt to do so. Avoid taking these medicines with drugs containing nitrates. Do not drink alcohol with either of these two medicines. It can result in low blood pressure and may cause heart attack/stroke etc.

The processing of these medicines takes place in the liver. Do not use them with drugs that change the action of some liver enzymes. You should notify your doctor about other medicines before using these ED drugs to prevent drug interactions. Using the two ED medicines with grapefruit juice should be avoided. It can increase the side effects of these medicines.

Discuss with your doctor about your health issues and medicines so that the doctor can help you know if these ED medicines will work for you or whether you should take them.

Frequently Asked Questions

Which medicine has a greater success rate?

Both medicines have similar success rates according to clinical trials. Both are effective in 80% of men using either of these drugs. According to studies, Tadalafil is the first choice of men.

Is a prescription required for Tadalafil or Sildenafil?

Both these medicines need a prescription. To get any of these ED medicines, visit your medical expert so that he evaluate your condition before giving a prescription.

Can I take both medicines together?

No. Do not take the two medicines together/on the same day. Using more than one ED pill on the same day or same time can cause unusual and harmful side effects. It can include nausea, dizziness, indigestion, nausea, and a painful erection that stays for more than four hours.

Is Tadalafil 20mg equivalent to Sildenafil 100mg?

These doses are the highest available doses for these medicines. Doctors prescribe higher doses only when lower doses fail to work. Both these should be used differently and also differ in the period of action.

Will Sildenafil offer harder erections than Tadalafil?

Well, Tadalafil has the same safety and efficiency as Sildenafil and helps men get sexual confidence. But, their partners choose Tadalafil over Sildenafil. Thus, Tadalafil can be a good option for treating ED.

Which medicine is better for me?

Different ED drugs work differently and one ED drug may not suit everyone. So, it is difficult to say which medicine works for you unless you try them. According to customer reviews and their experience, men prefer Tadalafil over Sildenafil because it works faster, and taking it with food is okay. On the other hand, some men do not find Tadalafil better as it doesn’t suit them. So, they stick to Sildenafil. It is about which Erectile Dysfunction medicine works for you.

You can go through the reviews online and speak to your sex expert to check out which ED medicine is best for you. After a complete assessment, your sex expert will guide you on using suitable ED medicine.


Before you know which ED medicine works for you, you should try it. Before trying it, speak to your sex expert, and discuss your ED or PE problem openly so that he knows the exact problem. Sometimes, ED occurs due to stress. In such cases, you need proper consultation first before taking any medicines. It is easy to treat ED now with affordable treatment options to help you have a better sex life.