Welcome to our comprehensive guide on MESACOL 400MG, a medication widely used to treat inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn's disease. As a leading authority in the field of medicine and healthcare, we aim to provide you with the most detailed and up-to-date information on this medication to help you understand its benefits, usage, potential side effects, and more.

What is MESACOL 400MG?

MESACOL 400MG is a brand-name medication containing mesalazine (also known as mesalamine) as its active ingredient. Mesalazine is classified as an anti-inflammatory drug, specifically an aminosalicylate, which is highly effective in managing the symptoms of various inflammatory bowel conditions. It works by reducing inflammation in the digestive tract, thereby providing relief to individuals suffering from ulcerative colitis and Crohn's disease.

How Does MESACOL 400MG Work?

MESACOL 400MG exerts its therapeutic effects directly on the inflamed intestinal tissue. When ingested, the mesalazine in MESACOL 400MG is released in the colon, where it comes into contact with the inflamed tissue. The drug's anti-inflammatory properties help to modulate the immune response responsible for the inflammation, leading to a reduction in symptoms like abdominal pain, diarrhea, and rectal bleeding.

Indications and Usage

MESACOL 400MG is primarily prescribed for the treatment of ulcerative colitis and mild to moderate Crohn's disease. Doctors may also prescribe it for other conditions not mentioned in the official label, depending on the patient's individual needs and medical history.

Dosage and Administration

The appropriate dosage of MESACOL 400MG varies depending on the severity of the disease, the patient's age, weight, and overall health. Typically, the recommended starting dose for adults is 800mg to 1600mg per day, divided into two or three doses. For maintenance therapy, the dosage may be reduced to 400mg to 800mg daily.

It is crucial to follow the doctor's instructions carefully and complete the full course of treatment even if symptoms improve. Abruptly stopping the medication can lead to a relapse of symptoms.

Possible Side Effects

Like any medication, MESACOL 400MG may cause side effects in some individuals. Common side effects may include nausea, headache, dizziness, and abdominal discomfort. Most of these side effects are mild and transient.

In rare cases, some patients may experience more severe side effects such as severe allergic reactions, kidney problems, or blood disorders. If you encounter any unusual or concerning symptoms, it is vital to seek immediate medical attention.

Precautions and Warnings

Before starting MESACOL 400MG, inform your doctor about any existing medical conditions, ongoing treatments, or known allergies. This will help the healthcare provider assess the suitability of the medication for your specific situation and adjust the dosage if needed.

It is essential to mention any history of kidney problems, liver disease, or blood disorders, as these conditions may affect the choice of treatment.

Drug Interactions

MESACOL 400MG may interact with other medications, vitamins, or herbal supplements you are taking. These interactions can alter the drug's effectiveness or increase the risk of side effects. It is crucial to provide a complete list of all medications you are using to your doctor or pharmacist before starting MESACOL 400MG.

Pregnancy and Breastfeeding

If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking MESACOL 400MG. The potential risks and benefits for both the mother and the unborn or nursing child should be carefully evaluated before starting the treatment.

Important Considerations

While MESACOL 400MG is highly effective in managing inflammatory bowel diseases, it is not a cure. It helps control the symptoms and reduce inflammation, but long-term management and lifestyle changes are necessary for a comprehensive treatment plan.

It is essential to attend all scheduled follow-up appointments with your healthcare provider to monitor your progress and adjust the treatment plan as needed.


In conclusion, MESACOL 400MG is a widely prescribed medication for the management of inflammatory bowel diseases like ulcerative colitis and Crohn's disease. Its active ingredient, mesalazine, is known for its anti-inflammatory properties, providing much-needed relief to patients suffering from these conditions.

As with any medication, it is crucial to follow the doctor's instructions, be aware of potential side effects, and communicate openly about your medical history and current medications. By doing so, you can ensure the most effective and safe treatment with MESACOL 400MG.

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